Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 03/12/21 21:00 | 03/12/21 21:00 | Granada CF | Deportivo Alaves | 2-1 | 2 - 5 points |
| 04/12/21 14:00 | 04/12/21 14:00 | FC Séville | Villarreal CF | 1-0 | 2 - 5 points |
| 04/12/21 16:15 | 04/12/21 16:15 | FC Barcelone | Bétis Séville | 0-1 | 2 - 5 points |
| 04/12/21 18:30 | 04/12/21 18:30 | Atletico Madrid | RCD Majorque | 1-2 | 2 - 5 points |
| 04/12/21 21:00 | 04/12/21 21:00 | Real Sociedad | Real Madrid | 0-2 | 2 - 5 points |
| 05/12/21 14:00 | 05/12/21 14:00 | Rayo Vallecano | Espanyol Barcelone | 1-0 | 2 - 5 points |
| 05/12/21 16:15 | 05/12/21 16:15 | FC Elche | FC Cadiz | 3-1 | 2 - 5 points |
| 05/12/21 18:30 | 05/12/21 18:30 | UD Levante | CA Osasuna | 0-0 | 2 - 5 points |
| 05/12/21 21:00 | 05/12/21 21:00 | Celta Vigo | Valence CF | 1-2 | 2 - 5 points |
| 06/12/21 21:00 | 06/12/21 21:00 | FC Getafe | Athletic Bilbao | 0-0 | 2 - 5 points |