Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 08/01/22 14:00 | 08/01/22 14:00 | UD Levante | RCD Majorque | 2-0 | 2 - 5 points |
| 08/01/22 16:15 | 08/01/22 16:15 | Real Sociedad | Celta Vigo | 1-0 | 2 - 5 points |
| 08/01/22 18:30 | 08/01/22 18:30 | Granada CF | FC Barcelone | 1-1 | 2 - 5 points |
| 08/01/22 21:00 | 08/01/22 21:00 | Real Madrid | Valence CF | 4-1 | 2 - 5 points |
| 09/01/22 14:00 | 09/01/22 14:00 | Rayo Vallecano | Bétis Séville | 1-1 | 2 - 5 points |
| 09/01/22 16:15 | 09/01/22 16:15 | FC Séville | FC Getafe | 1-0 | 2 - 5 points |
| 09/01/22 18:30 | 09/01/22 18:30 | CA Osasuna | FC Cadiz | 2-0 | 2 - 5 points |
| 09/01/22 18:30 | 09/01/22 18:30 | Deportivo Alaves | Athletic Bilbao | 0-0 | 2 - 5 points |
| 09/01/22 21:00 | 09/01/22 21:00 | Villarreal CF | Atletico Madrid | 2-2 | 2 - 5 points |
| 10/01/22 21:00 | 10/01/22 21:00 | Espanyol Barcelone | FC Elche | 1-2 | 2 - 5 points |