Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 11/02/22 21:00 | 11/02/22 21:00 | FC Séville | FC Elche | 2-0 | 2 - 5 points |
| 12/02/22 14:00 | 12/02/22 14:00 | FC Cadiz | Celta Vigo | 0-0 | 2 - 5 points |
| 12/02/22 16:15 | 12/02/22 16:15 | Villarreal CF | Real Madrid | 0-0 | 2 - 5 points |
| 12/02/22 18:30 | 12/02/22 18:30 | Rayo Vallecano | CA Osasuna | 0-3 | 2 - 5 points |
| 12/02/22 21:00 | 12/02/22 21:00 | Atletico Madrid | FC Getafe | 4-3 | 2 - 5 points |
| 13/02/22 14:00 | 13/02/22 14:00 | Deportivo Alaves | Valence CF | 2-1 | 2 - 5 points |
| 13/02/22 16:15 | 13/02/22 16:15 | UD Levante | Bétis Séville | 2-4 | 2 - 5 points |
| 13/02/22 18:30 | 13/02/22 18:30 | Real Sociedad | Granada CF | 2-0 | 2 - 5 points |
| 13/02/22 21:00 | 13/02/22 21:00 | Espanyol Barcelone | FC Barcelone | 2-2 | 2 - 5 points |
| 14/02/22 21:00 | 14/02/22 21:00 | RCD Majorque | Athletic Bilbao | 3-2 | 2 - 5 points |