Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 25/02/22 21:00 | 25/02/22 21:00 | UD Levante | FC Elche | 3-0 | 2 - 5 points |
| 26/02/22 14:00 | 26/02/22 14:00 | RCD Majorque | Valence CF | 0-1 | 2 - 5 points |
| 26/02/22 16:15 | 26/02/22 16:15 | FC Getafe | Deportivo Alaves | 2-2 | 2 - 5 points |
| 26/02/22 18:30 | 26/02/22 18:30 | Rayo Vallecano | Real Madrid | 0-1 | 2 - 5 points |
| 26/02/22 21:00 | 26/02/22 21:00 | Atletico Madrid | Celta Vigo | 2-0 | 2 - 5 points |
| 27/02/22 14:00 | 27/02/22 14:00 | Villarreal CF | Espanyol Barcelone | 5-1 | 2 - 5 points |
| 27/02/22 16:15 | 27/02/22 16:15 | FC Séville | Bétis Séville | 2-1 | 2 - 5 points |
| 27/02/22 18:30 | 27/02/22 18:30 | Real Sociedad | CA Osasuna | 1-0 | 2 - 5 points |
| 27/02/22 21:00 | 27/02/22 21:00 | FC Barcelone | Athletic Bilbao | 4-0 | 2 - 5 points |
| 28/02/22 21:00 | 28/02/22 21:00 | Granada CF | FC Cadiz | 0-0 | 2 - 5 points |