Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 17/09/21 21:00 | 17/09/21 21:00 | Celta Vigo | FC Cadiz | 1-2 | 2 - 5 points |
| 18/09/21 14:00 | 18/09/21 14:00 | Rayo Vallecano | FC Getafe | 3-0 | 2 - 5 points |
| 18/09/21 16:15 | 18/09/21 16:15 | Atletico Madrid | Athletic Bilbao | 0-0 | 2 - 5 points |
| 18/09/21 18:30 | 18/09/21 18:30 | FC Elche | UD Levante | 1-1 | 2 - 5 points |
| 18/09/21 21:00 | 18/09/21 21:00 | Deportivo Alaves | CA Osasuna | 0-2 | 2 - 5 points |
| 19/09/21 14:00 | 19/09/21 14:00 | RCD Majorque | Villarreal CF | 0-0 | 2 - 5 points |
| 19/09/21 16:15 | 19/09/21 16:15 | Real Sociedad | FC Séville | 0-0 | 2 - 5 points |
| 19/09/21 18:30 | 19/09/21 18:30 | Bétis Séville | Espanyol Barcelone | 2-2 | 2 - 5 points |
| 19/09/21 21:00 | 19/09/21 21:00 | Valence CF | Real Madrid | 1-2 | 2 - 5 points |
| 20/09/21 21:00 | 20/09/21 21:00 | FC Barcelone | Granada CF | 1-1 | 2 - 5 points |