Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 21/09/21 19:30 | 21/09/21 19:30 | FC Getafe | Atletico Madrid | 1-2 | 2 - 5 points |
| 21/09/21 22:00 | 21/09/21 22:00 | Athletic Bilbao | Rayo Vallecano | 1-2 | 2 - 5 points |
| 21/09/21 22:00 | 21/09/21 22:00 | UD Levante | Celta Vigo | 0-2 | 2 - 5 points |
| 22/09/21 19:30 | 22/09/21 19:30 | Espanyol Barcelone | Deportivo Alaves | 1-0 | 2 - 5 points |
| 22/09/21 19:30 | 22/09/21 19:30 | FC Séville | Valence CF | 3-1 | 2 - 5 points |
| 22/09/21 22:00 | 22/09/21 22:00 | Real Madrid | RCD Majorque | 6-1 | 2 - 5 points |
| 22/09/21 22:00 | 22/09/21 22:00 | Villarreal CF | FC Elche | 4-1 | 2 - 5 points |
| 23/09/21 19:30 | 23/09/21 19:30 | Granada CF | Real Sociedad | 2-3 | 2 - 5 points |
| 23/09/21 19:30 | 23/09/21 19:30 | CA Osasuna | Bétis Séville | 1-3 | 2 - 5 points |
| 23/09/21 22:00 | 23/09/21 22:00 | FC Cadiz | FC Barcelone | 0-0 | 2 - 5 points |