Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 25/09/21 14:00 | 25/09/21 14:00 | Deportivo Alaves | Atletico Madrid | 1-0 | 2 - 5 points |
| 25/09/21 16:15 | 25/09/21 16:15 | Valence CF | Athletic Bilbao | 1-1 | 2 - 5 points |
| 25/09/21 18:30 | 25/09/21 18:30 | FC Séville | Espanyol Barcelone | 2-0 | 2 - 5 points |
| 25/09/21 21:00 | 25/09/21 21:00 | Real Madrid | Villarreal CF | 0-0 | 2 - 5 points |
| 26/09/21 14:00 | 26/09/21 14:00 | RCD Majorque | CA Osasuna | 2-3 | 2 - 5 points |
| 26/09/21 16:15 | 26/09/21 16:15 | FC Barcelone | UD Levante | 3-0 | 2 - 5 points |
| 26/09/21 18:30 | 26/09/21 18:30 | Real Sociedad | FC Elche | 1-0 | 2 - 5 points |
| 26/09/21 18:30 | 26/09/21 18:30 | Rayo Vallecano | FC Cadiz | 3-1 | 2 - 5 points |
| 26/09/21 21:00 | 26/09/21 21:00 | Bétis Séville | FC Getafe | 2-0 | 2 - 5 points |
| 27/09/21 21:00 | 27/09/21 21:00 | Celta Vigo | Granada CF | 1-0 | 2 - 5 points |