Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 17/09/21 21:00 | 17/09/21 20:59 | Newcastle United | Leeds United | 1-1 | 2 - 4 points |
| 18/09/21 13:30 | 18/09/21 13:29 | Wolverhampton Wanderers | Brentford FC | 0-2 | 2 - 4 points |
| 18/09/21 16:00 | 18/09/21 15:59 | FC Burnley | FC Arsenal | 0-1 | 2 - 4 points |
| 18/09/21 16:00 | 18/09/21 15:59 | FC Liverpool | Crystal Palace | 3-0 | 2 - 4 points |
| 18/09/21 16:00 | 18/09/21 15:59 | Manchester City | FC Southampton | 0-0 | 2 - 4 points |
| 18/09/21 16:00 | 18/09/21 15:59 | Norwich City | FC Watford | 1-3 | 2 - 4 points |
| 18/09/21 18:30 | 18/09/21 18:29 | Aston Villa | FC Everton | 3-0 | 2 - 4 points |
| 19/09/21 15:00 | 19/09/21 14:59 | West Ham United | Manchester United | 1-2 | 2 - 4 points |
| 19/09/21 15:00 | 19/09/21 14:59 | Brighton and Hove Albion | Leicester City | 2-1 | 2 - 4 points |
| 19/09/21 17:30 | 19/09/21 17:29 | Tottenham Hotspur | FC Chelsea | 0-3 | 2 - 4 points |