Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 02/12/21 21:00 | 02/12/21 21:00 | Ajax Amsterdam | Willem II Tilburg | 5-0 | 2 - 4 points |
| 03/12/21 20:00 | 03/12/21 20:00 | FC Groningen | PEC Zwolle | 1-1 | 2 - 4 points |
| 04/12/21 16:30 | 04/12/21 16:30 | PSV Eindhoven | FC Utrecht | 4-1 | 2 - 4 points |
| 04/12/21 18:45 | 04/12/21 18:45 | Cambuur-Leeuwarden | Vitesse Arnheim | 1-6 | 2 - 4 points |
| 04/12/21 21:00 | 04/12/21 21:00 | Heracles Almelo | SC Heerenveen | 0-1 | 2 - 4 points |
| 05/12/21 12:15 | 05/12/21 12:15 | RKC Waalwijk | NEC Nijmwegen | 2-1 | 2 - 4 points |
| 05/12/21 14:30 | 05/12/21 14:30 | Go Ahead Eagles Deventer | FC Twente Enschede | 1-2 | 2 - 4 points |
| 05/12/21 14:30 | 05/12/21 14:30 | AZ Alkmaar | Sparta Rotterdam | 3-1 | 2 - 4 points |
| 05/12/21 16:45 | 05/12/21 16:45 | Feyenoord Rotterdam | Fortuna Sittard | 5-0 | 2 - 4 points |