Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 11/02/22 20:00 | 11/02/22 20:00 | Heracles Almelo | FC Utrecht | 1-0 | 2 - 4 points |
| 12/02/22 18:45 | 12/02/22 18:45 | Cambuur-Leeuwarden | PEC Zwolle | 3-4 | 2 - 4 points |
| 12/02/22 18:45 | 12/02/22 18:45 | FC Groningen | Fortuna Sittard | 0-1 | 2 - 4 points |
| 12/02/22 20:00 | 12/02/22 20:00 | Vitesse Arnheim | PSV Eindhoven | 0-5 | 2 - 4 points |
| 13/02/22 12:15 | 13/02/22 12:15 | Sparta Rotterdam | Willem II Tilburg | 1-0 | 2 - 4 points |
| 13/02/22 12:15 | 13/02/22 12:15 | Go Ahead Eagles Deventer | AZ Alkmaar | 1-4 | 2 - 4 points |
| 13/02/22 14:30 | 13/02/22 14:30 | RKC Waalwijk | Feyenoord Rotterdam | 0-2 | 2 - 4 points |
| 13/02/22 14:30 | 13/02/22 14:30 | SC Heerenveen | NEC Nijmwegen | 0-1 | 2 - 4 points |
| 13/02/22 16:45 | 13/02/22 16:45 | Ajax Amsterdam | FC Twente Enschede | 5-0 | 2 - 4 points |