Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 17/09/21 20:00 | 17/09/21 20:00 | Sparta Rotterdam | NEC Nijmwegen | 1-1 | 2 - 4 points |
| 18/09/21 16:30 | 18/09/21 16:30 | SC Heerenveen | Fortuna Sittard | 1-0 | 2 - 4 points |
| 18/09/21 18:45 | 18/09/21 18:45 | Willem II Tilburg | FC Groningen | 2-1 | 2 - 4 points |
| 18/09/21 20:00 | 18/09/21 20:00 | Ajax Amsterdam | Cambuur-Leeuwarden | 9-0 | 2 - 4 points |
| 18/09/21 21:00 | 18/09/21 21:00 | FC Utrecht | RKC Waalwijk | 2-2 | 2 - 4 points |
| 19/09/21 12:15 | 19/09/21 12:15 | Go Ahead Eagles Deventer | PEC Zwolle | 1-0 | 2 - 4 points |
| 19/09/21 14:30 | 19/09/21 14:30 | PSV Eindhoven | Feyenoord Rotterdam | 0-4 | 2 - 4 points |
| 19/09/21 16:45 | 19/09/21 16:45 | Vitesse Arnheim | FC Twente Enschede | 1-4 | 2 - 4 points |
| 19/09/21 16:45 | 19/09/21 16:45 | Heracles Almelo | AZ Alkmaar | 3-2 | 2 - 4 points |