Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 21/09/21 18:45 | 21/09/21 18:45 | Fortuna Sittard | Ajax Amsterdam | 0-5 | 2 - 4 points |
| 21/09/21 21:00 | 21/09/21 21:00 | RKC Waalwijk | Willem II Tilburg | 1-2 | 2 - 4 points |
| 22/09/21 18:45 | 22/09/21 18:45 | NEC Nijmwegen | FC Utrecht | 0-3 | 2 - 4 points |
| 22/09/21 18:45 | 22/09/21 18:45 | Go Ahead Eagles Deventer | PSV Eindhoven | 1-2 | 2 - 4 points |
| 22/09/21 20:00 | 22/09/21 20:00 | FC Groningen | Vitesse Arnheim | 0-1 | 2 - 4 points |
| 22/09/21 21:00 | 22/09/21 21:00 | PEC Zwolle | Sparta Rotterdam | 1-1 | 2 - 4 points |
| 22/09/21 21:00 | 22/09/21 21:00 | Feyenoord Rotterdam | SC Heerenveen | 3-1 | 2 - 4 points |
| 23/09/21 18:45 | 23/09/21 18:45 | Cambuur-Leeuwarden | Heracles Almelo | 2-1 | 2 - 4 points |
| 23/09/21 21:00 | 23/09/21 21:00 | FC Twente Enschede | AZ Alkmaar | 3-1 | 2 - 4 points |