Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 25/09/21 16:30 | 25/09/21 16:30 | Willem II Tilburg | PSV Eindhoven | 2-1 | 2 - 4 points |
| 25/09/21 18:45 | 25/09/21 18:45 | Vitesse Arnheim | Fortuna Sittard | 1-1 | 2 - 4 points |
| 25/09/21 18:45 | 25/09/21 18:45 | Ajax Amsterdam | FC Groningen | 3-0 | 2 - 4 points |
| 25/09/21 21:00 | 25/09/21 21:00 | FC Utrecht | PEC Zwolle | 5-1 | 2 - 4 points |
| 25/09/21 21:00 | 25/09/21 21:00 | Feyenoord Rotterdam | NEC Nijmwegen | 5-3 | 2 - 4 points |
| 26/09/21 12:15 | 26/09/21 12:15 | Sparta Rotterdam | Cambuur-Leeuwarden | 0-4 | 2 - 4 points |
| 26/09/21 14:30 | 26/09/21 14:30 | SC Heerenveen | FC Twente Enschede | 2-3 | 2 - 4 points |
| 26/09/21 14:30 | 26/09/21 14:30 | AZ Alkmaar | Go Ahead Eagles Deventer | 5-0 | 2 - 4 points |
| 26/09/21 16:45 | 26/09/21 16:45 | Heracles Almelo | RKC Waalwijk | 1-0 | 2 - 4 points |