Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 03/12/21 18:30 | 03/12/21 18:30 | Werder Bremen | Erzgebirge Aue | 4-0 | 2 - 5 points |
| 03/12/21 18:30 | 03/12/21 18:30 | SV Darmstadt 98 | Fortuna Düsseldorf | 1-3 | 2 - 5 points |
| 04/12/21 13:30 | 04/12/21 13:30 | 1. FC Nürnberg | Holstein Kiel | 2-1 | 2 - 5 points |
| 04/12/21 13:30 | 04/12/21 13:30 | SV Sandhausen | SC Paderborn 07 | 1-1 | 2 - 5 points |
| 04/12/21 13:30 | 04/12/21 13:30 | FC Hansa Rostock | FC Ingolstadt | 1-1 | 2 - 5 points |
| 04/12/21 20:30 | 04/12/21 20:30 | FC St. Pauli | FC Schalke 04 | 2-1 | 2 - 5 points |
| 05/12/21 13:30 | 05/12/21 13:30 | Hannover 96 | Hamburger SV | 1-0 | 2 - 5 points |
| 05/12/21 13:30 | 05/12/21 13:30 | Dynamo Dresden | Karlsruher SC | 3-1 | 2 - 5 points |
| 05/12/21 13:30 | 05/12/21 13:30 | 1. FC Heidenheim 1846 | Jahn Regensburg | 3-0 | 2 - 5 points |