Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 04/03/22 18:30 | 04/03/22 18:30 | SV Darmstadt 98 | 1. FC Heidenheim 1846 | 3-2 | 2 - 5 points |
| 04/03/22 18:30 | 04/03/22 18:30 | Holstein Kiel | SC Paderborn 07 | 3-4 | 2 - 5 points |
| 05/03/22 13:30 | 05/03/22 13:30 | FC St. Pauli | Karlsruher SC | 3-1 | 2 - 5 points |
| 05/03/22 13:30 | 05/03/22 13:30 | SV Sandhausen | Hannover 96 | 3-1 | 2 - 5 points |
| 05/03/22 13:30 | 05/03/22 13:30 | FC Schalke 04 | FC Hansa Rostock | 3-4 | 2 - 5 points |
| 05/03/22 20:30 | 05/03/22 20:30 | 1. FC Nürnberg | Hamburger SV | 2-1 | 2 - 5 points |
| 06/03/22 13:30 | 06/03/22 13:30 | Erzgebirge Aue | Jahn Regensburg | 1-0 | 2 - 5 points |
| 06/03/22 13:30 | 06/03/22 13:30 | Werder Bremen | Dynamo Dresden | 2-1 | 2 - 5 points |
| 06/03/22 13:30 | 06/03/22 13:30 | Fortuna Düsseldorf | FC Ingolstadt | 3-0 | 2 - 5 points |