Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 11/09/21 13:30 | 11/09/21 13:30 | FC Ingolstadt | Werder Bremen | 0-3 | 2 - 5 points |
| 11/09/21 13:30 | 11/09/21 13:30 | Karlsruher SC | Holstein Kiel | 2-2 | 2 - 5 points |
| 11/09/21 13:30 | 11/09/21 13:30 | Hannover 96 | FC St. Pauli | 1-0 | 2 - 5 points |
| 11/09/21 20:30 | 11/09/21 20:30 | Hamburger SV | SV Sandhausen | 2-1 | 2 - 5 points |
| 12/09/21 13:30 | 12/09/21 13:30 | Jahn Regensburg | 1. FC Nürnberg | 2-2 | 2 - 5 points |
| 12/09/21 13:30 | 12/09/21 13:30 | FC Hansa Rostock | SV Darmstadt 98 | 2-1 | 2 - 5 points |
| 12/09/21 13:30 | 12/09/21 13:30 | 1. FC Heidenheim 1846 | Dynamo Dresden | 2-1 | 2 - 5 points |
| 12/09/21 13:30 | 12/09/21 13:30 | SC Paderborn 07 | FC Schalke 04 | 0-1 | 2 - 5 points |
| 12/09/21 13:30 | 12/09/21 13:30 | Erzgebirge Aue | Fortuna Düsseldorf | 0-1 | 2 - 5 points |