Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 24/09/21 18:30 | 24/09/21 18:30 | 1. FC Heidenheim 1846 | SV Darmstadt 98 | 2-1 | 2 - 5 points |
| 24/09/21 18:30 | 24/09/21 18:30 | Jahn Regensburg | Erzgebirge Aue | 3-2 | 2 - 5 points |
| 25/09/21 13:30 | 25/09/21 13:30 | Karlsruher SC | FC St. Pauli | 1-3 | 2 - 5 points |
| 25/09/21 13:30 | 25/09/21 13:30 | SC Paderborn 07 | Holstein Kiel | 1-2 | 2 - 5 points |
| 25/09/21 13:30 | 25/09/21 13:30 | FC Ingolstadt | Fortuna Düsseldorf | 1-2 | 2 - 5 points |
| 25/09/21 20:30 | 25/09/21 20:30 | FC Hansa Rostock | FC Schalke 04 | 0-2 | 2 - 5 points |
| 26/09/21 13:30 | 26/09/21 13:30 | Hannover 96 | SV Sandhausen | 1-2 | 2 - 5 points |
| 26/09/21 13:30 | 26/09/21 13:30 | Dynamo Dresden | Werder Bremen | 3-0 | 2 - 5 points |
| 26/09/21 13:30 | 26/09/21 13:30 | Hamburger SV | 1. FC Nürnberg | 2-2 | 2 - 5 points |