| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 29/03/25 19:30 | New England Revolution | New York Red Bulls | 2-1 |
| 29/03/25 19:30 | Toronto FC | Vancouver Whitecaps | 0-0 |
| 29/03/25 21:30 | Colorado Rapids | Charlotte FC | 2-0 |
| 30/03/25 00:30 | Atlanta United FC | New York City FC | 4-3 |
| 30/03/25 00:30 | D.C. United | Columbus Crew | 1-2 |
| 30/03/25 00:30 | Inter Miami CF | Philadelphia Union | 2-1 |
| 30/03/25 01:30 | FC Dallas | Sporting Kansas City | 2-1 |
| 30/03/25 01:30 | Chicago Fire | CF Montreal | 1-1 |
| 30/03/25 01:30 | Minnesota United FC | Real Salt Lake | 2-0 |
| 30/03/25 01:30 | Nashville SC | Cincinnati FC | 1-2 |
| 30/03/25 04:30 | San Jose Earthquakes | Seattle Sounders | 1-1 |
| 30/03/25 04:30 | Los Angeles Galaxy | Orlando City | 1-2 |
| 30/03/25 04:30 | San Diego FC | Los Angeles FC | 3-2 |
| 30/03/25 20:15 | St. Louis City SC | Austin FC | 0-1 |
| 31/03/25 01:00 | Portland Timbers | Houston Dynamo | 3-1 |