| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|
| 05/11/21 20:30 | 05/11/21 20:00 | FSV Mayence 05 | Bor. Mönchengladbach | 1-1 | 2 - 4 points |
| 06/11/21 15:30 | 06/11/21 15:00 | VfB Stuttgart | Arminia Bielefeld | 0-1 | 2 - 4 points |
| 06/11/21 15:30 | 06/11/21 15:00 | VfL Wolfsburg | FC Augsburg | 1-0 | 2 - 4 points |
| 06/11/21 15:30 | 06/11/21 15:00 | Bayern Munich | SC Freiburg | 2-1 | 2 - 4 points |
| 06/11/21 15:30 | 06/11/21 15:00 | VfL Bochum | 1899 Hoffenheim | 2-0 | 2 - 4 points |
| 06/11/21 18:30 | 06/11/21 18:00 | RB Leipzig | Borussia Dortmund | 2-1 | 2 - 4 points |
| 07/11/21 15:30 | 07/11/21 15:00 | Hertha BSC | Bayer 04 Leverkusen | 1-1 | 2 - 4 points |
| 07/11/21 17:30 | 07/11/21 17:00 | 1. FC Cologne | 1. FC Union Berlin | 2-2 | 2 - 4 points |
| 07/11/21 19:30 | 07/11/21 19:00 | SpVgg Greuther Fürth | Eintracht Frankfurt | 1-2 | 2 - 4 points |
