| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|
| 03/12/21 20:30 | 03/12/21 20:00 | 1. FC Union Berlin | RB Leipzig | 2-1 | 2 - 4 points |
| 04/12/21 15:30 | 04/12/21 15:00 | FSV Mayence 05 | VfL Wolfsburg | 3-0 | 2 - 4 points |
| 04/12/21 15:30 | 04/12/21 15:00 | 1899 Hoffenheim | Eintracht Frankfurt | 3-2 | 2 - 4 points |
| 04/12/21 15:30 | 04/12/21 15:00 | Bayer 04 Leverkusen | SpVgg Greuther Fürth | 7-1 | 2 - 4 points |
| 04/12/21 15:30 | 04/12/21 15:00 | Arminia Bielefeld | 1. FC Cologne | 1-1 | 2 - 4 points |
| 04/12/21 15:30 | 04/12/21 15:00 | FC Augsburg | VfL Bochum | 2-3 | 2 - 4 points |
| 04/12/21 18:30 | 04/12/21 18:00 | Borussia Dortmund | Bayern Munich | 2-3 | 2 - 4 points |
| 05/12/21 15:30 | 05/12/21 15:00 | VfB Stuttgart | Hertha BSC | 2-2 | 2 - 4 points |
| 05/12/21 17:30 | 05/12/21 17:00 | Bor. Mönchengladbach | SC Freiburg | 0-6 | 2 - 4 points |
