| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|
| 25/02/22 20:30 | 25/02/22 20:00 | 1899 Hoffenheim | VfB Stuttgart | 2-1 | 2 - 4 points |
| 26/02/22 15:30 | 26/02/22 15:00 | SC Freiburg | Hertha BSC | 3-0 | 2 - 4 points |
| 26/02/22 15:30 | 26/02/22 15:00 | Bor. Mönchengladbach | VfL Wolfsburg | 2-2 | 2 - 4 points |
| 26/02/22 15:30 | 26/02/22 15:00 | 1. FC Union Berlin | FSV Mayence 05 | 3-1 | 2 - 4 points |
| 26/02/22 15:30 | 26/02/22 15:00 | Bayer 04 Leverkusen | Arminia Bielefeld | 3-0 | 2 - 4 points |
| 26/02/22 15:30 | 26/02/22 15:00 | SpVgg Greuther Fürth | 1. FC Cologne | 1-1 | 2 - 4 points |
| 26/02/22 18:30 | 26/02/22 18:00 | Eintracht Frankfurt | Bayern Munich | 0-1 | 2 - 4 points |
| 27/02/22 15:30 | 27/02/22 15:00 | VfL Bochum | RB Leipzig | 0-1 | 2 - 4 points |
| 27/02/22 17:30 | 27/02/22 17:00 | FC Augsburg | Borussia Dortmund | 1-1 | 2 - 4 points |
