| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|
| 17/09/21 20:30 | 17/09/21 20:00 | Hertha BSC | SpVgg Greuther Fürth | 2-1 | 2 - 4 points |
| 18/09/21 15:30 | 18/09/21 15:00 | Bayern Munich | VfL Bochum | 7-0 | 2 - 4 points |
| 18/09/21 15:30 | 18/09/21 15:00 | Arminia Bielefeld | 1899 Hoffenheim | 0-0 | 2 - 4 points |
| 18/09/21 15:30 | 18/09/21 15:00 | FC Augsburg | Bor. Mönchengladbach | 1-0 | 2 - 4 points |
| 18/09/21 15:30 | 18/09/21 15:00 | FSV Mayence 05 | SC Freiburg | 0-0 | 2 - 4 points |
| 18/09/21 18:30 | 18/09/21 18:00 | 1. FC Cologne | RB Leipzig | 1-1 | 2 - 4 points |
| 19/09/21 15:30 | 19/09/21 15:00 | VfB Stuttgart | Bayer 04 Leverkusen | 1-3 | 2 - 4 points |
| 19/09/21 17:30 | 19/09/21 17:00 | Borussia Dortmund | 1. FC Union Berlin | 4-2 | 2 - 4 points |
| 19/09/21 19:30 | 19/09/21 19:00 | VfL Wolfsburg | Eintracht Frankfurt | 1-1 | 2 - 4 points |
