| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|
| 24/09/21 20:30 | 24/09/21 20:00 | SpVgg Greuther Fürth | Bayern Munich | 1-3 | 2 - 4 points |
| 25/09/21 15:30 | 25/09/21 15:00 | Eintracht Frankfurt | 1. FC Cologne | 1-1 | 2 - 4 points |
| 25/09/21 15:30 | 25/09/21 15:00 | RB Leipzig | Hertha BSC | 6-0 | 2 - 4 points |
| 25/09/21 15:30 | 25/09/21 15:00 | 1899 Hoffenheim | VfL Wolfsburg | 3-1 | 2 - 4 points |
| 25/09/21 15:30 | 25/09/21 15:00 | 1. FC Union Berlin | Arminia Bielefeld | 1-0 | 2 - 4 points |
| 25/09/21 15:30 | 25/09/21 15:00 | Bayer 04 Leverkusen | FSV Mayence 05 | 1-0 | 2 - 4 points |
| 25/09/21 18:30 | 25/09/21 18:00 | Bor. Mönchengladbach | Borussia Dortmund | 1-0 | 2 - 4 points |
| 26/09/21 15:30 | 26/09/21 15:00 | VfL Bochum | VfB Stuttgart | 0-0 | 2 - 4 points |
| 26/09/21 17:30 | 26/09/21 17:00 | SC Freiburg | FC Augsburg | 3-0 | 2 - 4 points |
