Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 05/11/21 19:00 | 05/11/21 19:00 | Bor. Mönchengladbach II | Rot-Weiss Essen | 1-2 | 2 - 4 points |
| 05/11/21 19:00 | 05/11/21 19:00 | 1. FC Cologne II | Wuppertaler SV | 0-3 | 2 - 4 points |
| 05/11/21 19:30 | 05/11/21 19:30 | Alemannia Aachen | SV Straelen | 5-3 | 2 - 4 points |
| 05/11/21 19:30 | 05/11/21 19:30 | Preußen Münster | SV Lippstadt 08 | 3-1 | 2 - 4 points |
| 06/11/21 14:00 | 06/11/21 14:00 | SC Wiedenbrück | SC Fortuna Cologne | 0-1 | 2 - 4 points |
| 06/11/21 14:00 | 06/11/21 14:00 | Rot-Weiss Oberhausen | VfB Homberg | 3-1 | 2 - 4 points |
| 06/11/21 14:00 | 06/11/21 14:00 | KFC Uerdingen | Fortuna Düsseldorf II | 1-1 | 2 - 4 points |
| 06/11/21 14:00 | 06/11/21 14:00 | Sportfreunde Lotte | Rot-Weiss Ahlen | 4-1 | 2 - 4 points |
| 06/11/21 14:00 | 06/11/21 14:00 | FC Wegberg-Beeck | SV Rödinghausen | 1-1 | 2 - 4 points |
| 07/11/21 14:00 | 07/11/21 14:00 | Bonner SC | FC Schalke 04 II | 4-3 | 2 - 4 points |