Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 26/11/21 18:30 | 26/11/21 18:30 | Fortuna Düsseldorf II | Alemannia Aachen | 3-0 | 2 - 4 points |
| 26/11/21 19:00 | 26/11/21 19:00 | Preußen Münster | SC Wiedenbrück | 1-0 | 2 - 4 points |
| 26/11/21 19:30 | 26/11/21 19:30 | FC Schalke 04 II | KFC Uerdingen | 4-1 | 2 - 4 points |
| 27/11/21 14:00 | 27/11/21 14:00 | SV Straelen | FC Wegberg-Beeck | 0-0 | 2 - 4 points |
| 27/11/21 14:00 | 27/11/21 14:00 | VfB Homberg | 1. FC Cologne II | 1-3 | 2 - 4 points |
| 27/11/21 14:00 | 27/11/21 14:00 | SC Fortuna Cologne | Bor. Mönchengladbach II | 2-1 | 2 - 4 points |
| 27/11/21 14:00 | 27/11/21 14:00 | SV Lippstadt 08 | Rot-Weiss Oberhausen | 1-2 | 2 - 4 points |
| 27/11/21 14:00 | 27/11/21 14:00 | Bonner SC | Rot-Weiss Ahlen | 2-2 | 2 - 4 points |
| 27/11/21 14:00 | 27/11/21 14:00 | Rot-Weiss Essen | SV Rödinghausen | 1-0 | 2 - 4 points |
| 27/11/21 14:00 | 27/11/21 14:00 | Wuppertaler SV | Sportfreunde Lotte | 2-1 | 2 - 4 points |