Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 22/01/22 14:00 | 22/01/22 14:00 | Bor. Mönchengladbach II | FC Schalke 04 II | 1-4 | 2 - 4 points |
| 22/01/22 14:00 | 22/01/22 14:00 | Alemannia Aachen | SV Lippstadt 08 | 3-0 | 2 - 4 points |
| 22/01/22 14:00 | 22/01/22 14:00 | SV Straelen | Bonner SC | 0-0 | 2 - 4 points |
| 22/01/22 14:00 | 22/01/22 14:00 | SC Wiedenbrück | KFC Uerdingen | 5-1 | 2 - 4 points |
| 22/01/22 15:30 | 22/01/22 15:30 | 1. FC Cologne II | Rot-Weiss Oberhausen | 1-0 | 2 - 4 points |
| 23/01/22 14:00 | 23/01/22 14:00 | Rot-Weiss Essen | Wuppertaler SV | 2-1 | 2 - 4 points |
| 02/03/22 19:30 | 02/03/22 19:30 | Sportfreunde Lotte | Preußen Münster | 2-3 | 2 - 4 points |
| 16/03/22 19:30 | 16/03/22 19:30 | SV Rödinghausen | Fortuna Düsseldorf II | 4-1 | 2 - 4 points |
| 16/03/22 19:30 | 16/03/22 19:30 | FC Wegberg-Beeck | VfB Homberg | 2-1 | 2 - 4 points |
| 30/03/22 19:30 | 30/03/22 19:30 | Rot-Weiss Ahlen | SC Fortuna Cologne | 0-1 | 2 - 4 points |