Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 11/02/22 19:30 | 11/02/22 19:30 | SC Fortuna Cologne | Wuppertaler SV | 1-0 | 2 - 4 points |
| 12/02/22 14:00 | 12/02/22 14:00 | Preußen Münster | Rot-Weiss Ahlen | 2-0 | 2 - 4 points |
| 12/02/22 14:00 | 12/02/22 14:00 | Fortuna Düsseldorf II | SV Straelen | 0-4 | 2 - 4 points |
| 12/02/22 14:00 | 12/02/22 14:00 | VfB Homberg | Rot-Weiss Essen | 0-1 | 2 - 4 points |
| 12/02/22 14:00 | 12/02/22 14:00 | SC Wiedenbrück | Alemannia Aachen | 1-1 | 2 - 4 points |
| 12/02/22 14:00 | 12/02/22 14:00 | KFC Uerdingen | Bor. Mönchengladbach II | 1-4 | 2 - 4 points |
| 12/02/22 14:00 | 12/02/22 14:00 | Bonner SC | 1. FC Cologne II | 1-3 | 2 - 4 points |
| 13/02/22 14:00 | 13/02/22 14:00 | FC Schalke 04 II | SV Rödinghausen | 0-0 | 2 - 4 points |
| 09/03/22 18:00 | 09/03/22 18:00 | SV Lippstadt 08 | FC Wegberg-Beeck | 0-0 | 2 - 4 points |
| 30/03/22 19:30 | 30/03/22 19:30 | Rot-Weiss Oberhausen | Sportfreunde Lotte | 1-0 | 2 - 4 points |