Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 23/02/22 14:00 | 23/02/22 14:00 | 1. FC Cologne II | Bor. Mönchengladbach II | 2-0 | 2 - 4 points |
| 26/02/22 14:00 | 26/02/22 14:00 | SV Lippstadt 08 | Rot-Weiss Ahlen | 2-0 | 2 - 4 points |
| 26/02/22 14:00 | 26/02/22 14:00 | FC Schalke 04 II | Rot-Weiss Essen | 1-2 | 2 - 4 points |
| 26/02/22 14:00 | 26/02/22 14:00 | SV Rödinghausen | Rot-Weiss Oberhausen | 0-1 | 2 - 4 points |
| 26/02/22 14:00 | 26/02/22 14:00 | Alemannia Aachen | Bonner SC | 0-0 | 2 - 4 points |
| 26/02/22 14:00 | 26/02/22 14:00 | Preußen Münster | SV Straelen | 4-0 | 2 - 4 points |
| 26/02/22 14:00 | 26/02/22 14:00 | KFC Uerdingen | FC Wegberg-Beeck | 2-0 | 2 - 4 points |
| 26/02/22 14:00 | 26/02/22 14:00 | SC Wiedenbrück | Sportfreunde Lotte | 1-1 | 2 - 4 points |
| 26/02/22 14:00 | 26/02/22 14:00 | VfB Homberg | Wuppertaler SV | 0-2 | 2 - 4 points |
| 27/02/22 14:00 | 27/02/22 14:00 | Fortuna Düsseldorf II | SC Fortuna Cologne | 1-1 | 2 - 4 points |