Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 19/03/22 14:00 | 19/03/22 14:00 | Rot-Weiss Essen | KFC Uerdingen | 3-0 | 2 - 4 points |
| 19/03/22 14:00 | 19/03/22 14:00 | Sportfreunde Lotte | Bor. Mönchengladbach II | 2-0 | 2 - 4 points |
| 19/03/22 14:00 | 19/03/22 14:00 | FC Wegberg-Beeck | Alemannia Aachen | 0-2 | 2 - 4 points |
| 19/03/22 14:00 | 19/03/22 14:00 | SV Rödinghausen | 1. FC Cologne II | 2-1 | 2 - 4 points |
| 19/03/22 14:00 | 19/03/22 14:00 | Rot-Weiss Ahlen | SC Wiedenbrück | 1-0 | 2 - 4 points |
| 19/03/22 14:00 | 19/03/22 14:00 | SV Straelen | Rot-Weiss Oberhausen | 1-2 | 2 - 4 points |
| 19/03/22 14:00 | 19/03/22 14:00 | Wuppertaler SV | SV Lippstadt 08 | 3-0 | 2 - 4 points |
| 19/03/22 14:00 | 19/03/22 14:00 | VfB Homberg | Bonner SC | 0-3 | 2 - 4 points |
| 19/03/22 14:00 | 19/03/22 14:00 | SC Fortuna Cologne | FC Schalke 04 II | 2-2 | 2 - 4 points |
| 20/03/22 14:00 | 20/03/22 14:00 | Fortuna Düsseldorf II | Preußen Münster | 0-1 | 2 - 4 points |