Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 25/03/22 14:00 | 25/03/22 14:00 | FC Schalke 04 II | Fortuna Düsseldorf II | 0-4 | 2 - 4 points |
| 26/03/22 14:00 | 26/03/22 14:00 | Rot-Weiss Oberhausen | Wuppertaler SV | 1-1 | 2 - 4 points |
| 26/03/22 14:00 | 26/03/22 14:00 | Bor. Mönchengladbach II | FC Wegberg-Beeck | 0-1 | 2 - 4 points |
| 26/03/22 14:00 | 26/03/22 14:00 | KFC Uerdingen | SV Straelen | 4-1 | 2 - 4 points |
| 26/03/22 14:00 | 26/03/22 14:00 | Preußen Münster | VfB Homberg | 2-0 | 2 - 4 points |
| 26/03/22 14:00 | 26/03/22 14:00 | Bonner SC | Sportfreunde Lotte | 0-2 | 2 - 4 points |
| 26/03/22 14:00 | 26/03/22 14:00 | SC Wiedenbrück | Rot-Weiss Essen | 0-1 | 2 - 4 points |
| 26/03/22 14:00 | 26/03/22 14:00 | 1. FC Cologne II | Rot-Weiss Ahlen | 6-1 | 2 - 4 points |
| 26/03/22 14:00 | 26/03/22 14:00 | SV Lippstadt 08 | SC Fortuna Cologne | 0-2 | 2 - 4 points |
| 27/03/22 14:00 | 27/03/22 14:00 | Alemannia Aachen | SV Rödinghausen | 0-1 | 2 - 4 points |