Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 04/09/21 14:00 | 04/09/21 14:00 | SV Lippstadt 08 | Sportfreunde Lotte | 2-1 | 2 - 4 points |
| 04/09/21 14:00 | 04/09/21 14:00 | VfB Homberg | Rot-Weiss Ahlen | 1-2 | 2 - 4 points |
| 04/09/21 14:00 | 04/09/21 14:00 | FC Schalke 04 II | FC Wegberg-Beeck | 2-0 | 2 - 4 points |
| 04/09/21 14:00 | 04/09/21 14:00 | Rot-Weiss Oberhausen | Bor. Mönchengladbach II | 3-2 | 2 - 4 points |
| 04/09/21 14:00 | 04/09/21 14:00 | Preußen Münster | SV Rödinghausen | 0-0 | 2 - 4 points |
| 04/09/21 14:00 | 04/09/21 14:00 | KFC Uerdingen | Alemannia Aachen | 0-0 | 2 - 4 points |
| 04/09/21 14:00 | 04/09/21 14:00 | SC Fortuna Cologne | SV Straelen | 1-0 | 2 - 4 points |
| 04/09/21 14:00 | 04/09/21 14:00 | Bonner SC | Wuppertaler SV | 1-2 | 2 - 4 points |
| 28/09/21 19:30 | 28/09/21 19:30 | SC Wiedenbrück | 1. FC Cologne II | 2-0 | 2 - 4 points |
| 27/10/21 19:30 | 27/10/21 19:30 | Fortuna Düsseldorf II | Rot-Weiss Essen | 3-3 | 2 - 4 points |