Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 10/09/21 18:30 | 10/09/21 18:30 | SV Rödinghausen | FC Schalke 04 II | 1-0 | 2 - 4 points |
| 10/09/21 19:00 | 10/09/21 19:00 | Alemannia Aachen | SC Wiedenbrück | 0-1 | 2 - 4 points |
| 10/09/21 19:30 | 10/09/21 19:30 | 1. FC Cologne II | Bonner SC | 3-2 | 2 - 4 points |
| 10/09/21 19:30 | 10/09/21 19:30 | Rot-Weiss Essen | VfB Homberg | 3-0 | 2 - 4 points |
| 10/09/21 19:30 | 10/09/21 19:30 | Rot-Weiss Ahlen | Preußen Münster | 1-1 | 2 - 4 points |
| 11/09/21 14:00 | 11/09/21 14:00 | FC Wegberg-Beeck | SV Lippstadt 08 | 2-3 | 2 - 4 points |
| 11/09/21 14:00 | 11/09/21 14:00 | Wuppertaler SV | SC Fortuna Cologne | 1-1 | 2 - 4 points |
| 11/09/21 14:00 | 11/09/21 14:00 | SV Straelen | Fortuna Düsseldorf II | 1-1 | 2 - 4 points |
| 11/09/21 14:00 | 11/09/21 14:00 | Bor. Mönchengladbach II | KFC Uerdingen | 0-0 | 2 - 4 points |
| 27/10/21 19:30 | 27/10/21 19:30 | Sportfreunde Lotte | Rot-Weiss Oberhausen | 1-2 | 2 - 4 points |