Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 14/09/21 18:30 | 14/09/21 18:30 | SC Wiedenbrück | Bor. Mönchengladbach II | 0-0 | 2 - 4 points |
| 14/09/21 19:00 | 14/09/21 19:00 | Preußen Münster | Rot-Weiss Essen | 2-3 | 2 - 4 points |
| 14/09/21 19:30 | 14/09/21 19:30 | FC Schalke 04 II | Rot-Weiss Ahlen | 5-3 | 2 - 4 points |
| 15/09/21 18:00 | 15/09/21 18:00 | SV Lippstadt 08 | SV Rödinghausen | 0-2 | 2 - 4 points |
| 15/09/21 19:00 | 15/09/21 19:00 | Fortuna Düsseldorf II | Wuppertaler SV | 1-2 | 2 - 4 points |
| 15/09/21 19:30 | 15/09/21 19:30 | Bonner SC | SC Fortuna Cologne | 0-2 | 2 - 4 points |
| 15/09/21 19:30 | 15/09/21 19:30 | Rot-Weiss Oberhausen | FC Wegberg-Beeck | 0-0 | 2 - 4 points |
| 15/09/21 19:30 | 15/09/21 19:30 | 1. FC Cologne II | Alemannia Aachen | 1-3 | 2 - 4 points |
| 06/10/21 19:30 | 06/10/21 19:30 | VfB Homberg | SV Straelen | 0-1 | 2 - 4 points |
| 06/10/21 19:30 | 06/10/21 19:30 | KFC Uerdingen | Sportfreunde Lotte | 2-0 | 2 - 4 points |