Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 17/09/21 19:30 | 17/09/21 19:30 | Rot-Weiss Essen | FC Schalke 04 II | 1-0 | 2 - 4 points |
| 18/09/21 14:00 | 18/09/21 14:00 | Wuppertaler SV | VfB Homberg | 3-1 | 2 - 4 points |
| 18/09/21 14:00 | 18/09/21 14:00 | FC Wegberg-Beeck | KFC Uerdingen | 1-1 | 2 - 4 points |
| 18/09/21 14:00 | 18/09/21 14:00 | SV Straelen | Preußen Münster | 0-4 | 2 - 4 points |
| 18/09/21 14:00 | 18/09/21 14:00 | Bor. Mönchengladbach II | 1. FC Cologne II | 3-1 | 2 - 4 points |
| 18/09/21 14:00 | 18/09/21 14:00 | Rot-Weiss Oberhausen | SV Rödinghausen | 2-1 | 2 - 4 points |
| 18/09/21 14:00 | 18/09/21 14:00 | Rot-Weiss Ahlen | SV Lippstadt 08 | 1-1 | 2 - 4 points |
| 19/09/21 14:00 | 19/09/21 14:00 | SC Fortuna Cologne | Fortuna Düsseldorf II | 0-0 | 2 - 4 points |
| 19/09/21 14:00 | 19/09/21 14:00 | Bonner SC | Alemannia Aachen | 1-1 | 2 - 4 points |
| 10/11/21 19:30 | 10/11/21 19:30 | Sportfreunde Lotte | SC Wiedenbrück | 0-2 | 2 - 4 points |