Calendrier
| Date | Clôture des pronostics | À domicile | A l'extérieur | Résultat | Règle des points |
|---|---|---|---|---|---|
| 25/09/21 14:00 | 25/09/21 14:00 | SV Lippstadt 08 | Rot-Weiss Essen | 1-2 | 2 - 4 points |
| 25/09/21 14:00 | 25/09/21 14:00 | FC Schalke 04 II | SV Straelen | 1-1 | 2 - 4 points |
| 25/09/21 14:00 | 25/09/21 14:00 | Rot-Weiss Oberhausen | Rot-Weiss Ahlen | 4-0 | 2 - 4 points |
| 25/09/21 14:00 | 25/09/21 14:00 | Bonner SC | Fortuna Düsseldorf II | 0-3 | 2 - 4 points |
| 25/09/21 14:00 | 25/09/21 14:00 | VfB Homberg | SC Fortuna Cologne | 0-0 | 2 - 4 points |
| 25/09/21 14:00 | 25/09/21 14:00 | SC Wiedenbrück | FC Wegberg-Beeck | 1-1 | 2 - 4 points |
| 25/09/21 14:00 | 25/09/21 14:00 | KFC Uerdingen | SV Rödinghausen | 1-2 | 2 - 4 points |
| 25/09/21 14:00 | 25/09/21 14:00 | 1. FC Cologne II | Sportfreunde Lotte | 4-0 | 2 - 4 points |
| 25/09/21 16:00 | 25/09/21 16:00 | Alemannia Aachen | Bor. Mönchengladbach II | 0-1 | 2 - 4 points |
| 26/09/21 14:00 | 26/09/21 14:00 | Preußen Münster | Wuppertaler SV | 0-0 | 2 - 4 points |