| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 22/05/22 17:00 | FC Chelsea | FC Watford | 2-1 |
| 22/05/22 17:00 | Crystal Palace | Manchester United | 1-0 |
| 22/05/22 17:00 | Leicester City | FC Southampton | 4-1 |
| 22/05/22 17:00 | FC Liverpool | Wolverhampton Wanderers | 3-1 |
| 22/05/22 17:00 | Manchester City | Aston Villa | 3-2 |
| 22/05/22 17:00 | Norwich City | Tottenham Hotspur | 0-5 |
| 22/05/22 17:00 | FC Arsenal | FC Everton | 5-1 |
| 22/05/22 17:00 | Brentford FC | Leeds United | 1-2 |
| 22/05/22 17:00 | Brighton and Hove Albion | West Ham United | 3-1 |
| 22/05/22 17:00 | FC Burnley | Newcastle United | 1-2 |