| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 18/05/21 21:15 | CD Tondela | FC Pacos de Ferreira | 2-3 |
| 19/05/21 19:00 | FC Porto | Belenenses Lisbonne | 4-0 |
| 19/05/21 21:00 | SC Portimonense | Sporting Braga | 0-0 |
| 19/05/21 21:00 | Moreirense FC | FC Famalicao | 3-0 |
| 19/05/21 21:00 | Nacional Funchal | Rio Ave FC | 1-2 |
| 19/05/21 21:00 | CD Santa Clara | SC Farense | 4-0 |
| 19/05/21 21:00 | FC Gil Vicente | Boavista Porto | 1-2 |
| 19/05/21 21:00 | Vitoria Guimaraes | Benfica Lisbonne | 1-3 |
| 19/05/21 22:45 | Sporting Lisbonne | Maritimo Funchal | 5-1 |