| Date | À domicile | A l'extérieur | Résultat |
|---|---|---|---|
| 22/05/21 20:45 | Cagliari Calcio | FC Genua 1893 | 0-1 |
| 22/05/21 20:45 | FC Crotone | AC Florenz | 0-0 |
| 22/05/21 20:45 | Sampdoria Genua | Parma Calcio 1913 | 3-0 |
| 23/05/21 15:00 | Inter Milan | Udinese Calcio | 5-1 |
| 23/05/21 20:45 | Spezia Calcio | AS Rome | 2-2 |
| 23/05/21 20:45 | Atalanta Bergamo | AC Milan | 0-2 |
| 23/05/21 20:45 | FC Bologna | Juventus Turin | 1-4 |
| 23/05/21 20:45 | Sassuolo Calcio | Lazio Rom | 2-0 |
| 23/05/21 20:45 | SSC Naples | Hellas Verona | 1-1 |
| 23/05/21 20:45 | FC Turin | Benevento Calcio | 1-1 |